The
Network was founded by Dr. Gary S. Hoffman (Chairman of the Cleveland Clinic
Center for Vasculitis Care and Research) in 1991 while he served as the
Head of The Vasculitis and Related Diseases Section at the National Institutes
of Health. The Network infrastructure was moved to the Cleveland Clinic
Foundation when he arrived in 1992. In the ensuing years the membership
of The Network has grown from 15 to 55 institutions that are located throughout
the world.
Each INSSYS
member institution is represented by a principal investigator who is well
known for their work in some aspect of inflammatory vascular disease. INSSYS
has been responsible for a number of multi-center studies since its inception.
The largest studies include: (1) an evaluation of the utility of methotrexate
in the treatment of giant cell arteritis (21 institutions participated in
this effort) and (2) an evaluation of the utility of Enbrel (sTNF receptor)
in Wegener’s granulomatosis (8 center study).
Dr. John Stone serves as the Chairman (Johns Hopkins Vasculitis Center).
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